Diana Karpman Selected Research

Shiga Toxin (Shigella Toxin)

5/2021	Annexin Induces Cellular Uptake of Extracellular Vesicles and Delays Disease in Escherichia coli O157:H7 Infection.
1/2021	Isolation and Characterization of Shiga Toxin-Associated Microvesicles.
10/2020	Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit.
1/2020	Shiga Toxin-Bearing Microvesicles Exert a Cytotoxic Effect on Recipient Cells Only When the Cells Express the Toxin Receptor.
10/2019	Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism.
11/2017	Microvesicle Involvement in Shiga Toxin-Associated Infection.
1/2017	Haemolytic uraemic syndrome.
10/2016	Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome.
3/2015	Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome.
2/2015	A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles.

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Diana Karpman Research Topics

Disease

18	Hemolytic-Uremic Syndrome 05/2021 - 03/2006
13	Inflammation (Inflammations) 01/2022 - 08/2002
13	Infections 05/2021 - 02/2002
10	Atypical Hemolytic Uremic Syndrome 01/2021 - 03/2007
8	Thrombosis (Thrombus) 01/2022 - 03/2006
8	Vasculitis (Vasculitides) 01/2021 - 06/2009
8	Thrombotic Thrombocytopenic Purpura 02/2019 - 06/2003
7	IGA Glomerulonephritis (IGA Nephropathy) 01/2021 - 02/2010
7	Hemolysis 01/2021 - 03/2006
7	Renal Insufficiency (Renal Failure) 11/2017 - 03/2006
6	Thrombocytopenia (Thrombopenia) 02/2019 - 06/2003
4	Acute Kidney Injury (Acute Renal Failure) 01/2021 - 01/2013
4	Thrombotic Microangiopathies 01/2021 - 02/2017
4	Urinary Tract Infections (Urinary Tract Infection) 01/2021 - 08/2007
3	Kidney Diseases (Kidney Disease) 01/2021 - 01/2012
3	Glomerulonephritis 09/2019 - 10/2010
3	Diarrhea 10/2014 - 03/2006
2	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2021 - 10/2018
2	Colitis 11/2017 - 10/2014
2	Vascular System Injuries 11/2013 - 03/2009
2	Hemolytic Anemia 03/2009 - 06/2003
2	Fever (Fevers) 03/2009 - 06/2003
2	Disease Susceptibility (Diathesis) 08/2007 - 04/2007
1	Lupus Nephritis 01/2021
1	Ischemia 01/2021
1	Nephritis 01/2021
1	Thrombocytopenic Purpura (Thrombopenic Purpura) 02/2019
1	Chronic Renal Insufficiency 09/2017
1	Nephrotic Syndrome (Syndrome, Nephrotic) 09/2017
1	Cystic Kidney Diseases (Cystic Kidney Disease) 09/2017
1	Fabry Disease (Fabry's Disease) 01/2017
1	Rare Diseases (Rare Disease) 01/2017
1	Cystinosis 01/2017
1	Complement Component 6 Deficiency 01/2016
1	Meningococcal Infections 01/2016
1	Bacteremia 02/2015
1	Anemia 01/2012
1	Muscle Cramp (Cramp) 01/2012
1	Neoplasms (Cancer) 05/2011
1	Malignant Hypertension 01/2011
1	Streptococcal Infections (Streptococcal Infection) 10/2010
1	Purpura 02/2010
1	IgA Vasculitis (Purpura, Schoenlein Henoch) 02/2010
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2010

Drug/Important Bio-Agent (IBA)

19	Complement System Proteins (Complement)IBA 01/2022 - 03/2006
15	Shiga Toxin (Shigella Toxin)IBA 05/2021 - 03/2006
8	KininsIBA 01/2022 - 08/2002
8	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 02/2006
7	thiamine triphosphorate (TTP)IBA 02/2019 - 06/2003
5	Immunoglobulin A (IgA)IBA 11/2014 - 03/2002
5	Proteins (Proteins, Gene)FDA Link 07/2014 - 03/2002
4	eculizumab FDA Link 01/2017 - 01/2013
4	von Willebrand FactorIBA 03/2009 - 03/2006
3	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2021 - 11/2014
3	ADAMTS13 ProteinIBA 02/2017 - 03/2006
3	Thromboplastin (Tissue Factor)IBA 01/2015 - 03/2006
3	LipopolysaccharidesIBA 09/2009 - 02/2002
3	Fibrinogen (Factor I)FDA Link 11/2008 - 03/2007
2	Complement C3-C5 Convertases (C3 Convertase)IBA 01/2021 - 02/2012
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2017
2	Peptide Hydrolases (Proteases)FDA Link 02/2017 - 03/2009
2	Peptides (Polypeptides)IBA 07/2011 - 06/2009
2	Complement Factor H (Factor H)IBA 01/2011 - 06/2008
2	NucleotidesIBA 01/2011 - 07/2009
2	Toll-Like Receptor 4IBA 05/2010 - 08/2007
2	BradykininIBA 06/2009 - 06/2009
1	AngiotensinsIBA 01/2022
1	Biological ProductsIBA 01/2022
1	Kallikreins (Kallikrein)IBA 01/2022
1	ReninIBA 01/2022
1	AnnexinsIBA 05/2021
1	Complement Factor D (Factor D)IBA 01/2021
1	Complement Factor B (Factor B)IBA 01/2021
1	Quetiapine Fumarate (Seroquel)FDA Link 02/2019
1	aliskiren FDA Link 10/2018
1	LigandsIBA 01/2017
1	agalsidase beta FDA Link 01/2017
1	Cysteamine (Mercaptamine)FDA Link 01/2017
1	Pharmaceutical PreparationsIBA 01/2017
1	Edetic Acid (EDTA)FDA Link 03/2015
1	Purinergic P2 Receptors (ADP Receptor)IBA 03/2015
1	Hemoglobins (Hemoglobin)IBA 03/2015
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 03/2015
1	Suramin (Suramin Sodium)IBA 03/2015
1	Pathogen-Associated Molecular Pattern MoleculesIBA 10/2014
1	Interleukin-6 (Interleukin 6)IBA 07/2014
1	Galactose (Galactopyranose)FDA LinkGeneric 07/2014
1	galactosyl-deficient IgA1IBA 07/2014
1	Shiga Toxin 2IBA 09/2013
1	Bacterial ToxinsIBA 01/2012
1	Antimicrobial PeptidesIBA 01/2012
1	CathelicidinsIBA 01/2012
1	Iohexol (Omnipaque)FDA Link 05/2011
1	Amino Acids FDA Link 05/2011
1	Messenger RNA (mRNA)IBA 01/2010
1	Glutamine (L-Glutamine)FDA Link 07/2009

Therapy/Procedure

4	Kidney Transplantation 01/2021 - 03/2006
4	Therapeutics 01/2016 - 04/2009
2	Drug Therapy (Chemotherapy) 01/2019 - 05/2011
1	Peritoneal Dialysis 01/2013